The organism spends its strength fighting other diseases, and eventually the organism's resistance decreases. For example, in diabetes mellitus, there is a low resistance to infection.

d) State of the nervous system.

Long-term stresses lead to impairments in the functioning of the immune system. With stress, the level of stress hormones rises.

Imagine a crowded bus, and it is difficult for us to get to the exit, and it is difficult for immune cells to find viruses, bacteria and neutralize them, since they are prevented from doing this in this situation. The weakened immune system simply passes, does not see viruses, and those, in turn, already lead to diseases.

4. But there are also factors that directly destroy the immune system, and also act on the genotype of the cell, leading to mutations. This is radiation. High doses cause the formation of malignant neoplasms.

5. Chemical carcinogens.

How do these substances cause cancer? This is possibly due to the accumulation of enzymes in cells that catalyze demethylation, and primarily methyltransferase, which is responsible for starting these processes.

Thymine also has a methyl group. Methylation of cytosine, that is, the transfer of the methyl group from the acceptor to cytosine, is catalyzed by methyltransferase and leads to the formation of 5-methylcytosine. This is an important step of demethylation. It allows you to determine from which point the process should start. The work of methyltransferase indicates which methyl group passes into 5-hydroxymethylcytosine.

Therefore, it can be assumed that the accumulation of methyltransferase, Tet-proteins under the influence of various factors: viruses, genetic predisposition, immune status, chemical carcinogens – trigger the mechanisms of pathological DNA replication.

Thus, the transformation RM of DNA is associated with a change in the number of electrons, respectively, the force of the action of electrostatic repulsive forces between complementary pairs changes, and this leads to a voltage in chemical bonds. When passing into cytosine, the DNA section unwinds. Violation of these processes in genes encoding the synthesis of enzymes involved in demethylation can lead to hyperactivation of the entire DNA, with the subsequent formation of a tumor.

Sources

1. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine. By Shinsuke Ito, Li Shen, Qing Dai, Susan C. Wu, Leonard B. Collins, James A. Swenberg, Chuan He, Yi Zhang. Science. Vol.333.NO. 6047. 02 Sep 2011: 1300-1303.

2. Уотсон, Джеймс Д. Двойная спираль Воспоминания об открытии структуры ДНК: [Пер. с англ.: Брухнов, М.; Иорданский, А.] = Watson, James D. The Double Helix. A Personal Account of the Discovery of the Structure of DNA. Atheneum: New York, 1968. – М.: Мир, 1969. – 152 с.

3. Vanyushin B.F. Molecular biology // History of biology from the beginning of the XX century to the present day. M.: Science. 1975. p. 454.